APA
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Makuyana, N., Seldeslachts, L., Michiels, L., Burton, O. T., Hernandez, A. R., Ghodsinia, A., … Liston, A. (2026). Gene delivery of immunomodulatory cytokines to the lung preserves respiratory function during inflammatory challenge. Science Immunology.
Chicago/Turabian
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Makuyana, N., L. Seldeslachts, Lauren Michiels, Oliver T. Burton, Alvaro R. Hernandez, Arman Ghodsinia, E. Rahman, et al. “Gene Delivery of Immunomodulatory Cytokines to the Lung Preserves Respiratory Function during Inflammatory Challenge.” Science immunology (2026).
MLA
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Makuyana, N., et al. “Gene Delivery of Immunomodulatory Cytokines to the Lung Preserves Respiratory Function during Inflammatory Challenge.” Science Immunology, 2026.
BibTeX Click to copy
@article{n2026a,
title = {Gene delivery of immunomodulatory cytokines to the lung preserves respiratory function during inflammatory challenge},
year = {2026},
journal = {Science immunology},
author = {Makuyana, N. and Seldeslachts, L. and Michiels, Lauren and Burton, Oliver T. and Hernandez, Alvaro R. and Ghodsinia, Arman and Rahman, E. and Kops, Laura M. and Singh, Kailash and Naranjo, Francisco and Ali, Magda and Dashwood, Amy and Achkir, M. and Kouser, Lubna and Lienart, Stephanie and Guillaume, Stéphane M. and Naesens, L. and Linterman, M. and Wauters, J. and Joulia, Régis and Humblet-Baron, Stephanie and Velde, G. Vande and Dooley, James and Liston, A.}
}
Respiratory infections that result in severe and life-threatening immune-mediated respiratory decline are a major public health issue. Controlling local respiratory immune reactions without the use of systemic immunosuppressants remains an unmet clinical challenge. We developed a gene delivery system to express anti-inflammatory cytokines in the lung, which reestablishes local immune homeostasis without triggering systemic effects. Using an adeno-associated vector cargo system (AAV6.2- CC10 ), we induced production of interleukin-2 (IL-2), IL-1 receptor antagonist (IL-1RA), and IL-10 in situ in the lung microenvironment, with no detectable expression or immunological deviation in the peripheral immune system. We demonstrate the effective potential of IL-2, IL-1RA, and IL-10 as immunomodulatory cargos in severe infectious challenge, which reduced respiratory pathology after influenza-associated pulmonary aspergillosis. Thus, the AAV6.2- CC10 platform enables targeted delivery of biologics to the lung, modulates the lung environment, and improves pathology without inducing systemic immune reactions.