A single-cell spatial chart of the airway wall reveals proinflammatory cellular ecosystems and their interactions in health and asthma

R. Joulia, Sara Patti, W. Traves, Lola E Loewenthal, Laura Yates, S. Walker, F. Puttur, May Al-Sahaf, Katherine N. Cahill, Juying Lai, Salman Siddiqui, Joshua A. Boyce, Elliot Israel, Clare M. Lloyd

Nature Immunology, 2025

Location, Location, Location: Spatial Immune-Stroma Crosstalk Drives Pathogenesis in Asthma

R. Joulia, C. M. Lloyd

Immunological Reviews, vol. 330, 2025, pp. e70013

Location matters: defining the architecture of the bronchial wall in health and asthma

R. Joulia, Clare M Lloyd

Nature Immunology, 2025

Basophils: Regulators of lung inflammation over space and time

R. Joulia, Clare M. Lloyd

Journal of Experimental Medicine, 2024

Investigation into the lung vasculature transcriptional signature during asthma using spatial transcriptomic

R. Joulia, W. Traves, F. Puttur, L. Yates, S. Siddiqui, S. Saglani, C. Lloyd

01.01 - Lung Science Conference 2024, 2024

Mast cell activation disrupts interactions between endothelial cells and pericytes during early life allergic asthma

Régis Joulia, Franz Puttur, Helen Stölting, William J. Traves, Lewis J. Entwistle, Anastasia Voitovich, Minerva Garcia Martín, May Al-Sahaf, Katie Bonner, Elizabeth Scotney, Philip L. Molyneaux, Richard J. Hewitt, Simone A. Walker, Laura Yates, Sejal Saglani, Clare M. Lloyd

The Journal of Clinical Investigation, vol. 134, 2024, pp. e173676

Gene delivery of immunomodulatory cytokines to the lung preserves respiratory function during inflammatory challenge

N. Makuyana, L. Seldeslachts, Lauren Michiels, Oliver T. Burton, Alvaro R. Hernandez, Arman Ghodsinia, E. Rahman, Laura M. Kops, Kailash Singh, Francisco Naranjo, Magda Ali, Amy Dashwood, M. Achkir, Lubna Kouser, Stephanie Lienart, Stéphane M. Guillaume, L. Naesens, M. Linterman, J. Wauters, Régis Joulia, Stephanie Humblet-Baron, G. Vande Velde, James Dooley, A. Liston

Science immunology, 2026

Redefining airway wall immune–epithelial interactions using single-cell spatial transcriptomics

E. Rutherford, Sara Patti, W. Traves, Lola E Loewenthal, S. Siddiqui, Laura Yates, Simone A. Walker, F. Puttur, R. Joulia, Clare M. Lloyd

Airway cell biology and immunopathology, 2026

Epithelial cell-derived lumican modulates extracellular matrix dynamics in early-life airways disease.

F. Puttur, W. Traves, M. G. Martin, Samuele Di Carmine, F. Fercoq, D. C. Gaboriau, Lewis J Entwistle, Laura Yates, R. Joulia, Sara Patti, Helen Stoelting, Ciara Campbell, Mindy L Gore, S. Walker, Lola E Loewenthal, P. Molyneaux, Leo M. Carlin, S. Saglani, Clare M Lloyd

Journal of Allergy and Clinical Immunology, 2025

Mast Cells Promote Inflammatory Th17 Cells and Impair Treg Cells Through an IL-1β and PGE2 Axis

E. Leveque, Régis Joulia, Louise Battut, Camille Laurent, Salvatore Valitutti, Nicolas Cénac, Gilles Dietrich, Eric Espinosa

Journal of Inflammation Research, 2025

Matrix Metalloproteinase-12 Supports Pulmonary B Cell Follicle Formation and Local Antibody Responses During Asthma

C. J. Pyle, D. Patel, T. Peiró, R. Joulia, A. Grabiec, T. Hussell, G. Tavernier, A. Simpson, James Pease, J. Harker, C. Lloyd, R. Snelgrove

American Journal of Respiratory and Critical Care Medicine, 2022

Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A

R. Joulia, I. M. Guerrero-Fonseca, Tamara Girbl, J. A. Coates, Monja Stein, Laura Vázquez-Martínez, Eleanor Lynam, J. Whiteford, M. Schnoor, D. Voehringer, Axel Roers, S. Nourshargh, M. Voisin

Nature Communications, 2022

Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage

A. Barkaway, Loïc Rolas, R. Joulia, J. Bodkin, Tchern Lenn, Charlotte Owen-Woods, Natalia Reglero-Real, Monja Stein, Laura Vázquez-Martínez, Tamara Girbl, R. Poston, M. Golding, Rebecca S. Saleeb, Aude Thiriot, U. V. von Andrian, J. Duchêne, M. Voisin, C. Bishop, D. Voehringer, Axel Roers, A. Rot, T. Lämmermann, S. Nourshargh

Immunity, 2021

T helper cell-licensed mast cells promote inflammatory Th17 cells

E. Leveque, Régis Joulia, Camille Petitfils, Xavier Mas-Orea, Gaëlle Payros, C. Laurent, Nicolas Gaudenzio, G. Dietrich, S. Valitutti, N. Cenac, E. Espinosa

bioRxiv, 2021

Local microvascular leakage promotes trafficking of activated neutrophils to remote organs

Charlotte Owen-Woods, R. Joulia, A. Barkaway, Loïc Rolas, B. Ma, A. Nottebaum, K. Arkill, Monja Stein, Tamara Girbl, M. Golding, D. Bates, D. Vestweber, M. Voisin, S. Nourshargh

Journal of Clinical Investigation, 2020

Direct monitoring of basophil degranulation by using avidin-based probes.

Régis Joulia, C. Mailhol, S. Valitutti, A. Didier, E. Espinosa

Journal of Allergy and Clinical Immunology, 2017

IL‐33 fine tunes mast cell degranulation and chemokine production at the single‐cell level

Régis Joulia, F. L'Faqihi, S. Valitutti, E. Espinosa

Journal of Allergy and Clinical Immunology, 2017

The Mast Cell Antibody-Dependent Degranulatory Synapse.

S. Valitutti, Régis Joulia, E. Espinosa

Methods in molecular biology, 2017

Etude de la dynamique de dégranulation des mastocytes et analyse de l'effet des éicosanoïdes dans la coopération entre mastocytes et lymphocytes T Helper

Régis Joulia

2016

Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence

Régis Joulia, Nicolas Gaudenzio, Magda Rodrigues, Jodie Lopez, N. Blanchard, S. Valitutti, E. Espinosa

Nature Communications, 2015

Vectorial Exposure and Fusion Of Secretory Granule Content At The Mast Cell Degranulatory Synapse

Nicolas Gaudenzio, Régis Joulia, S. Valitutti, E. Espinosa

2014